| Specific cytotoxic T lymphocyte responses in Chinese HIV/AIDS patients |
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| 引用本文： | 尚红 韩晓旭 王亚男 周立平 张子宁 姜拥军 张旻 于旭. Specific cytotoxic T lymphocyte responses in Chinese HIV/AIDS patients[J]. 中华医学杂志(英文版), 2004, 117(10): 1570-1572 |
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| 作者姓名： | 尚红 韩晓旭 王亚男 周立平 张子宁 姜拥军 张旻 于旭 |
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| 作者单位： | [1]AIDSResearchCenter,FirstAffiliatedHospital,ChinaMedicalUniversity,Shenyang110001,China [2]PartnersAIDSResearchCenter,InfectiousDiseaseDivision,MassachusettsGeneralHospital,HarvardMedicalSchool,Boston,MA02129,USA |
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| 基金项目： | Thisstudywassupportedbythe“Tenth Five”NationalScienceandTechnologyTacklingofKeyProblemsProjectoftheScienceandTechnologyMinistryofChina (No 2 0 0 1BA70 5B0 1) |
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| 摘 要： | Human immunodeficiency virus type 1 ( HIV-1 )-specific cytotoxic T lymphocytes (CTL) are considered to play a central role in the immune response against HIV-1. During untreated acute HIV-1 infection, virus-specific CTL activity is associated with the initial decrease in viremia. After HIV infection, those individuals with a slow progressive course develop stronger CTL responses than those with typical disease progression. 2,3 Restoring HIV-1-specific CTL responses have been considered a key factor in immune reconstitution and vaccine development. Here we present the analysis of HIV-1 Gag-specific CTL responses in 23 Chinese HIV/AIDS cases in order to take the initial steps at identifying the epitopes that dominate the CTL response in Chinese patients.
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| 关 键 词： | CTL HIV-1 HIV／AIDS |
Specific cytotoxic T lymphocyte responses in Chinese HIV/AIDS patients |
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| Abstract: | |
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| Keywords: | HIV-1 T-lymphocytes, cytotoxic HIV-1 Gag |
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