Synthesis and rheological activity of new 1,2,4-triazole derivatives

Reactions of 3,5-dibromo-1,2,4-triazoles containing thietane or thietane-1,1-dioxide with thioglycolic acid yielded 2-[1-(thietanyl-3)-or 2-[1-(1,1-dioxothietanyl-3)-3-bromo-1,2,4-triazolyl-5-thio]acetic acids. Their salts have also been synthesized via reactions with amines and alkalis. Evaluation of the rheological properties showed that some of the synthesized compounds exhibited antiaggregant activity with respect to erythrocytes that was comparable with the effect of pentoxifylline. Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 9, pp. 15–17, September, 2008.