Microbial transformation of hederagenin by Cunninghamella echinulate,Mucor subtilissimus,and Pseudomonas oleovorans |
| |
| Authors: | Zhen Liu Yan-Hua Lu Ying-Xin Zou Zhuo Diao |
| |
| Institution: | 1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;3. Navy Medical Research Institute, Shanghai 200433, China;4. College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China |
| |
| Abstract: | The pentacyclic triterpenoid hederagenin (1) was subjected to biotransformation by Cunninghamella echinulate CGMCC 3.2000, Mucor subtilissimus CGMCC 3.2454 and Pseudomonas oleovorans CGMCC 1.1641. Three metabolites were obtained. On the basis of nuclear magnetic resonance and high-resolution mass spectral analyses, their structures were characterized as 3β, 23-dihydroxyolean-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester (2), 3β, 15α, 23-trihydroxyolean-12-en-28-oic acid (3), 1β, 3β, 23-trihydroxyolean-12-en-28-oic acid (4), and metabolite (3) was a new compound. This was the first report on the biotransformation of hederagenin. |
| |
| Keywords: | Microbial transformation triterpenoid hederagenin Cunninghamella echinulate Mucor subtilissimus Pseudomonas oleovorans |
|
|
