Two new phenols from Lysimachia patungensis |
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Authors: | Yuan-Yuan Gao Peng Zeng Cheng-Lin Jia |
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Institution: | 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Yueyang Hospital and Clinical Research Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China |
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Abstract: | Two new phenols, methyl 3-(2-O-β-d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate (1) and myricetin-3,3′,5′-tri-O-α-l-rhamnopyranoside (2), together with six known phenols compounds (3–8), were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz. Their structures were elucidated on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, UV, IR, and NMR. All the known phenols were isolated from the genus Lysimachia for the first time. A preliminary bioassay revealed that compounds 3 and 7 exhibited significant protective effects against hydrogen peroxide-induced damage in human retinal endothelial cells (HRECs) with the concentration of 10 μM, respectively. Compound 1 showed moderate activity against the HRECs damage at 100 μM. |
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Keywords: | Primulaceae Lysimachia patungensis phenols d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate" target="_blank">methyl 3-(2-O-β-d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate myricetin-3 3′ l-rhamnopyranoside" target="_blank">5′-tri-O-α-l-rhamnopyranoside antioxidant activity |
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