Aspergchromones A and B,two new polyketides from the marine sponge-associated fungus Aspergillus sp. SCSIO XWS03F03 |
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| Authors: | Ying Wang Xiu-Ping Lin Zhi-Ran Ju Xiao-Jian Liao Xiao-Jun Huang Chen Zhang |
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| Affiliation: | 1. Department of Chemistry, Jinan University, Guangzhou 510632, China;2. Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;3. College of Pharmacy, Jinan University, Guangzhou 510632, China |
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| Abstract: | Two new polyketides, aspergchromones A (1) and B (2), together with five known compounds, secalonic acid D (3), noreugenin (4), (3S)-5-hydroxymellein (5), (4S)-6-hydroxyisosclerone (6), and (-)-regiolone (7), were isolated from the ethyl acetate extract of marine sponge-derived fungus Aspergillus sp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound 3 showed moderate antimicrobial activity. |
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| Keywords: | Aspergillus sp. SCSIO XWS03F03 polyketides antimicrobial |
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