Design,synthesis and antibreast cancer MCF-7 cells biological evaluation of heterocyclic analogs of resveratrol |
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Authors: | Cheng Du Ming-Hui Dong Lu Jin Cheng Xu |
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Affiliation: | School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China |
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Abstract: | A new series of resveratrol heterocyclic analogs (4a–m) were designed and synthesized, and their inhibitiory effects on MCF-7 cells were evaluated to investigate structure–activity relationship. The effects of these analogs on human breast cancer MCF-7 cells were also determined. Results showed that MCF-7 cells could be inhibited more potently by these analogs than by resveratrol (IC50 = 80.0 μM). Among the analogs, compounds 4c, 4e, and 4k showed a significantly higher activity (IC50 = 42.7, 48.1, and 43.4 μM) than resveratrol. Furthermore, the derivatives without additional heterocyclic structure in the 4′-OH position exhibited a more potent activity than that with addition heterocyclic structure. In addition, docking simulation was performed to adequately position compound 4c in a human F1-ATPase active site to determine a probable binding model. These heterocyclic analogs could be effective candidates for the chemoprevention of human breast cancer. |
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Keywords: | Heterocyclic analogs of resveratrol breast cancer MCF-7 cells molecular docking |
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