| N-乙基-N-甲基氨基甲酰氯的简便合成 |
| |
| 引用本文： | 李梅,周鸣强,邓勇. N-乙基-N-甲基氨基甲酰氯的简便合成[J]. 华西药学杂志, 2008, 23(5) |
| |
| 作者姓名： | 李梅 周鸣强 邓勇 |
| |
| 作者单位： | 四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041;四川大学华西药学院,四川,成都,610041 |
| |
| 摘 要： | 目的 研究N-乙基-N-甲基氨基甲酰氯的简便合成方法 .方法 以苯甲醛和乙胺水溶液为起始原料,形成Schiff碱后经硫酸二甲酯甲基化、水解、中和,得N-甲基乙胺,再与三光气反应得N-乙基-N-甲基氨基甲酰氯.结果 目的 化合物的化学结构经<'1> HNMR确证,总收率为57.1%.结论 改进的合成方法 具有原料易得、条件温和、操作简便、收率高等优点.
|
| 关 键 词： | 重酒石酸利斯的明 胆碱酯酶抑制剂 N-甲基乙胺 N-乙基-N-甲基氨基甲酰氯 合成 |
A convenient synthesis of N-ethyl-N-methylcarbamoyl chloride |
| |
| LI Mei,ZHOU Ming-qiang,DENG Yong. A convenient synthesis of N-ethyl-N-methylcarbamoyl chloride[J]. West China Journal of Pharmaceutical Sciences, 2008, 23(5) |
| |
| Authors: | LI Mei ZHOU Ming-qiang DENG Yong |
| |
| Abstract: | OBJECTIVE To investigate a practical and convenient process for the synthesis of N-ethyl-N-methylcarbamoyl chloride.METHODS N-methylethylamine was synthesized from benzaldehyde and ethylamine aqueous solution.The key steps included methylation of N-benzylideneethylamine by dimethyl sulfate,followed by hydrolyzation and neutralization with sodium hydroxide.N-methylethylamine then was reacted with triPhogene to afford the N-ethyl-N-methylcarbamoyl chloride.RESULTS The chemical structure of target compound was determined by 1HNMR.The overall yield was 57.1%.CONCLUSION This Process,as compared to reported methods,has the advantages of milder reaction condition,simpler process and higher yield. |
| |
| Keywords: | Rivastigmine hydrogentartrate Cholinesterase inhibitor N-methylethylamine N-ethyl-N-methylcarbamoyl chloride Synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
