| 肿瘤发生的表观遗传学:进展与临床意义 |
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| 引用本文： | 王先火,赵秀娟,邱立华,王华庆,王玺. 肿瘤发生的表观遗传学:进展与临床意义[J]. 北京大学学报(医学版), 2012, 44(5): 701-707 |
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| 作者姓名： | 王先火 赵秀娟 邱立华 王华庆 王玺 |
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| 作者单位： | 天津市肿瘤医院,天津医科大学附属肿瘤医院淋巴瘤科,天津300060;天津医科大学基础医学院细胞生物学系,天津,300070;天津市肿瘤医院,天津医科大学附属肿瘤医院淋巴瘤科,天津300060;天津医科大学基础医学院细胞生物学系,天津 300070;Dana Farber Cancer Institute,Harvard Medical School,Boston,MA 02215,USA |
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| 摘 要： | 表观遗传(epigenetics)指所有不通过DNA序列改变就能影响基因表达(从而决定细胞乃至个体表型)的、可遗传的(即可伴随细胞分裂传递下去)调控方式,包括DNA甲基化、组蛋白修饰、染色质重塑、miRNA、朊病毒等。表观遗传调控在干细胞自我更新、定向分化、器官发育等生命过程中起着至关重要的作用:每一个多细胞生物个体都是由一个受精
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| 关 键 词： | 表观遗传 肿瘤 DNA甲基化 组蛋白修饰 染色质组装和分解 |
Epigenetics in tumorigenesis:advances and clinical implications |
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| WANG Xi. Epigenetics in tumorigenesis:advances and clinical implications[J]. Journal of Peking University. Health sciences, 2012, 44(5): 701-707 |
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| Authors: | WANG Xi |
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| Affiliation: | WANG Xian-huo1,ZHAO Xiu-juan2,QIU Li-hua1,WANG Hua-qing1,WANG Xi1,2,3(1.Department of Lymphoma,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300060,China;2.Department of Cell Biology,Basic Medical College of Tianjin Medical University,Tianjin 300070,China;3.Dana Farber Cancer Institute,Harvard Medical School,Boston,MA 02215,USA) |
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| Abstract: | Cancer is a leading cause of death worldwide and the total number of cases globally keeps increasing.For many years,cancer has been thought to be caused by a series of DNA sequence alterations and thus is thought to be a "genetic"disease.However,studies in the last decade,including the large-scale cancer genomics projects,have highlighted the rising importance of epigenetic regulation in cancer.Here,we review recent advances in understanding how chromatin-based epigenetic regulation participates in tumorigenesis and discuss the growing implications of these advances for developing novel strategies to prevent,diagnose,as well as treat cancer. |
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| Keywords: | Epigenetics Neoplasms DNA methylation Histones Chromatin remodeling |
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