脑利钠肽对天性心脏病患儿体外循环前后早期心功能评价

目的观察先天性心脏病患儿开胸直视手术前后血浆脑利钠肽（BNP）及其前体（NT-pro-BNP）的水平,评价先心病患儿手术前后心功能的变化。方法选择2008年7月至2009年1月在武警广东总队医院心胸外科住院的先天性心脏病患儿40例（心脏病组）,及同期门诊健康对照儿童30例（对照组）,用酶联免疫吸附法定量测定血浆BNP及NT-pro-BNP浓度。结果心脏病组CBP前与健康组对比、CBP前与CBP结束时及术后24h对比,结果均有统计学意义。结论说明利用BNP及NT-pro-BNP血浆浓度评价手术前后早期心功能的变化,对预防术后心衰、低心排的发生有重要意义。

Brain Natriuretic Peptide to Evaluate the Early Cardiac Function in Children with Congenital Heart Disease before and after CBP

Objective To observe the level of（BNP）and its precursor（NT-pro-BNP）before and after the surgery in children with heart disease,and evaluate the heart function.Methods To select 40 cases of children with heart disease（heart group） lived in the Guangdong Armed Police Corps Hospital from 2008.7 to 2009.1 and 30cases of healthy control（control group）in the same period in the hospital and acquired the venous blood.To detect the concentration of（BNP）and its precursor（NT-pro-BNP）of the plasma using the method of enzyme-linked immunosorbent assay.Results The comparetion between pre-CBP group with heart disease and health control group、between pre-CBP group and the end of CBP group、and between pre-CBP group and 24 hours after CBP group are all have statistically significance using the method of detecting the level of BNP and NT-pro-BNP in plasma.Conclusion It is important that use of BNP and NT-pro-BNP plasma concentrations to evaluation the change of early cardiac function before and after surgery for prevention of postoperative heart failure and the incidence of low cardiac output.