| IL-6促进胰岛细胞胰岛素分泌在PCOS发病机制中的作用 |
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| 引用本文： | 洪岭,伍园园,唐传玲,陈淼鑫,赵美,滕晓明. IL-6促进胰岛细胞胰岛素分泌在PCOS发病机制中的作用[J]. 同济大学学报(医学版), 2017, 38(1): 40-43 |
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| 作者姓名： | 洪岭 伍园园 唐传玲 陈淼鑫 赵美 滕晓明 |
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| 作者单位： | 同济大学附属第一妇婴保健院生殖医学中心,上海 201204,同济大学附属第一妇婴保健院生殖医学中心,上海 201204,同济大学附属第一妇婴保健院生殖医学中心,上海 201204,同济大学附属第一妇婴保健院生殖医学中心,上海 201204,同济大学附属第一妇婴保健院生殖医学中心,上海 201204,同济大学附属第一妇婴保健院生殖医学中心,上海 201204 |
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| 摘 要： | 目的 探讨IL-6在多囊卵巢综合征(polycystic ovary syndrome, PCOS)高胰岛素血症和胰岛素抵抗中的作用。方法 在体外培养的大鼠胰岛细胞培养液中加入10、100和1000pg/ml IL-6,于培养24、48、72h后,采用放射免疫法检测IL-6对胰岛细胞胰岛素分泌的影响。结果 培育48h时,1000pg/ml IL-6板孔中的胰岛素浓度高于对照组,差异有统计学意义(P＜0.05)；培育72h时,100、1000pg/ml IL-6板孔中的胰岛素浓度均高于对照组,差异有统计学意义(P＜0.05)。结论 IL-6在体外具有刺激胰岛细胞分泌胰岛素的作用,这可能与PCOS患者常出现高胰岛素血症、胰岛素抵抗现象有关。
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| 关 键 词： | 白介素6 多囊卵巢综合征 胰岛素抵抗 胰岛 |
| 收稿时间： | 2016-11-14 |
IL-6 induces insulin secretion in rat pancreatic islet cells in vitro |
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| HONG Ling,WU Yuan-yuan,TANG Chuan-ling,CHEN Miao-xin,ZHAO Mei and TENG Xiao-ming. IL-6 induces insulin secretion in rat pancreatic islet cells in vitro[J]. Journal of Tongji University(Medical Science), 2017, 38(1): 40-43 |
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| Authors: | HONG Ling WU Yuan-yuan TANG Chuan-ling CHEN Miao-xin ZHAO Mei TENG Xiao-ming |
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| Affiliation: | Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China,Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China,Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China,Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China,Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China and Reproductive Medicine Center, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai 201204, China |
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| Abstract: | ObjectiveTo investigate the effect of interlukin-6 (IL-6) on insulin secretion in rat pancreatic islet cells in vitro. Methods Primarily cultured pancreatic islet cells were treated with IL-6 at concentration of 10,0 and 1000pg/ml, respectively. The insulin contents in culture supernatant were detected by radioimmunoassay (RIA) at 24,8 and 72h after culture. ResultsThe insulin levels in culture supernatant with IL-6 1000pg/ml at 48h after culture were significantly higher than those in controls (P<0.05). The insulin levels in supernatant with IL-6 100pg/ml and 1000pg/ml were significantly higher than those controls at 72h after treatment. Conclusion IL-6 can induce insulin secretion in pancreatic islet cells in vitro, which may be associated with hyperinsulinemia and insulin resistance involved in polycystic ovarian syndrome. |
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| Keywords: | interlukin-6 polycystic ovary syndrome insulin resistance pancreatic islet |
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