A new furostanol saponin from <Emphasis Type="Italic">Asparagus cochinchinensis</Emphasis> |
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Authors: | Yang Shen Cong-Li Xu Wei-Dong Xuan Hui-Liang Li Run-Hui Liu Xi-Ke Xu Hai-Sheng Chen |
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Institution: | (1) College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, No. 103 Wenhua Road, 110016 Shenyang, Liaoning, People’s Republic of China; |
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Abstract: | A new furostanol saponin, (25S)-26-O-β-d-glucopyranosyl-5β-furost-20(22)-en-3β, 15β,26-triol-3-O-α-l-rhamnopyranosyl-(1–4)]-β-d-glucopyranoside, namely, aspacochioside D (1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C (2), (25S)-5β-spirostan-3β-yl-O-O-α-l-rhamnopyranosyl-(1–4)]-β-d-glucopyranoside (3), and pseudoprotoneodioscin (4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, 1H-NMR, 13C-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1–4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC50 value of 3.87 μg/mL. |
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