| C-erbB-1及C-erbB-2癌基因蛋白在外阴鳞癌及癌前病变中的表达 |
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| 引用本文： | 王康敏,苏宝山,黄莺,陈晓黎,刘恩让,薛翔.C-erbB-1及C-erbB-2癌基因蛋白在外阴鳞癌及癌前病变中的表达[J].中国皮肤性病学杂志,1998(6). |
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| 作者姓名： | 王康敏 苏宝山 黄莺 陈晓黎 刘恩让 薛翔 |
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| 作者单位： | 西安医科大学第二附属医院病理科，西安医科大学第二附属医院皮肤科，西安医科大学第二附属医院妇产科 |
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| 摘 要： | 目的：探讨原癌基因Ｃ ｅｒｂＢ １、Ｃ ｅｒｂＢ ２和外阴癌发生的关系。方法：应用免疫组化ＡＢＣ法检测了１３２例外阴病变中原癌基因Ｃ ｅｒｂＢ １和Ｃ ｅｒｂＢ ２的表达。结果：两种癌基因在正常皮肤、外阴各型营养不良、不典型增生和鳞癌中的表达不同（Ｐ＜０．０５）。在各级鳞癌中表达则相反。结论：提示Ｃ ｅｒｂＢ １和Ｃ ｅｒｂＢ ２在外阴鳞状上皮增生、癌变和鳞癌生长的不同阶段均有不同作用。
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| 关 键 词： | C-erbB-1癌基因 C-erbB-2癌基因 外阴肿瘤 癌前病变 免疫组织化学 |
The expression of C erbB 1 and C erbB 2 oncogene in squamous cell carcinoma and precancerous lesion of vulva. |
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| Wand Kangmin,Su Baoshan,Huang Ying,et al..The expression of C erbB 1 and C erbB 2 oncogene in squamous cell carcinoma and precancerous lesion of vulva.[J].The Chinese Journal of Dermatovenereology,1998(6). |
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| Authors: | Wand Kangmin Su Baoshan Huang Ying |
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| Institution: | Wand Kangmin,Su Baoshan,Huang Ying,et al.Department of pathology,Second Affiliated Hospital,Xi'an Medical University,Xi'an,710004 |
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| Abstract: | Objective:To study the relationship between oncogenes C erbB 1,C erbB 2 and vulva carcinogenesis.Method:The expression of C erbB 1 and C erbB 2 oncogene was investigated by ABC technique of immunohistochemioloigy in 132 cases of vulva lesion.Results:The Expression among normal skin,various dystrophy,atypical hyperplasia,squanmous carcinama had significant difference( P <0.05).Expression showed a significant positive correlation in squamous carcinoma.Conclusion:The results suggested theat the C erbB 1 and C erbB 2 play diffrent roles in squamous cell proliferation,canceration and squamous carcinomas. |
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| Keywords: | C erbB 1 C erbB 2 Vulvar neoplasms Precancerous lesion Immunohistochemistry |
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