紫杉醇联合卡铂或顺铂治疗老年晚期NSCLC

目的比较紫杉醇（TAX）联合卡铂（CBP）方案与紫杉醇联合顺铂（DDP）方案治疗老年晚期非小细胞肺癌（NSCLC）的临床疗效。方法88例老年晚期NSCLC随机分为两组TAX＋CBP组（TC组）44例和TAX＋DDP组（TP组）44例。观察治疗后两组有效率及毒副反应的情况。结果TC组与TP组的总有效率分别为24．0％和26．0％，差异无统计学意义（P〉0．05）；TC组胃肠道反应、肝肾功能异常、周围神经病变等毒副反应轻于TP方案组（P〈O．05）。结论TC方案和TP方案治疗老年晚期NSCLC的疗效相似，但TC方案的毒副反应较轻，为较理想的方案。

Clinical analysis of combined chemotherapy of paclitaxel plus carboplatin and paclitaxel plus cisplatin for elderly advanced non-small-cell lung cancer

Objective To compare the efficacy of combined chemotherapy regimen of paclitaxel plus carboplatin(TC) and paclitaxel plus cisplatin(TP) for elderly advanced non-small-cell lung cancer(NSCLC).Methods All 80 elderly patients with advanced NSCLC were divided into TC group of 44 cases and TP group of 44 cases.Results The overall response rates were 24.0% in the TC group,and 26.0% in the TP group.The main toxicities in the TP group were gastrointestinal reaction,renal damage and central nervous system toxicity.Conclusion TC regimen and TP regimen in the treatment of elderly patients with advanced NSCLC have similar efficacy,but the toxicity of TC regimen is lighter,TC regimen is an ideal regimen for advanced non-small-cell lung cancer.