脑利钠肽对川崎病患儿冠状动脉与心肌损伤的影响

目的探讨脑利钠肽对川崎病患儿冠状动脉与心肌损伤的影响情况。方法根据筛选标准，自2005年选取60例确诊为KD的患儿为研究组，同时选取60例正常同龄儿童为对照组。于入院治疗时、恢复期分别检测研究组患儿WBC、CRP、cTnI、BNP及测量冠状动脉内径。对照组患儿仅健康体检时检测1次。结果急性治疗期，研究组KD患儿WBC、CRP、BNP及cTnI水平，均高于对照组（P〈0．01，P〈0．05）。恢复期，研究组WBC、BNP水平亦均高于对照组（P〈0．05）。完全KD患儿的冠状动脉受累情况，无论从扩张百分比及冠脉内径厚度而言均低于不完全KD患儿（P〈0．01．P〈0．05）。结论BNP水平升高不仅作为KD的诊断标志物，也为临床预测冠状动脉及心肌损伤提供了新方法。

Influence of levels of serum brain natriuretic peptide on coronary and myocardial injury in children with Kawasaki disease

Objective To study serum levels of brain natriuretic peptide(BNP) in children with Kawasaki disease(KD) and the correlation between BNP levels and the heart function.Methods All of 60 children with KD and 60 healthy children were enrolled.Serum levels of BNP were measured using ELISA.KD children received an echocardiographic examination,including measurements of WBC,CRP,cTnI,BNP and measurement of coronary arterial diameter.Results Acute treatment period,study group with KD WBC,CRP,BNP and cTnI levels,were higher than those of control group(P < 0.01,P < 0.05).The recovery period,research group WBC,BNP levels were higher than those in control group(P < 0.05).The complete KD with coronary artery involvement,whether from the expansion percentage and coronary diameter thickness were lower than the incomplete KD children(P < 0.01,P < 0.05).Conclusion The serum BNP levels increase significantly in KD children at the acute stage,and is useful for the early diagnosis of KD.