老年人群高尿酸血症患病率调查及相关心血管危险因素研究

目的调查我地区老年人群高尿酸血症的患病率，分析多种相关心血管危险因素与高尿酸血症之间的相互关系。方法选取我市部分社区中大于60岁的老年人1281例进行高尿酸血症流行病学调查，了解老年人血糖、血压、血脂、体重指数等多种心血管危险因素情况。结果①本市部分社区老年人群高尿酸血症的患病率为18．5％。②高尿酸血症组的吸烟、饮酒率、高血压、冠心病患病率较血尿酸水平正常组升高，差异有统计学意义（P〈0．05），脑卒中、糖尿病患病率虽高于血尿酸水平正常组，但差异无统计学意义（P〉0．05）。③高尿酸血症组TG、TC、SBP、DBP、LDL—C水平明显高于血尿酸水平正常组，差异有统计学意义（P〈0．05），HDL—C水平明显低于血尿酸水平正常组，差异有统计学意义（P〈0．05）；BMI、FPG水平虽高于血尿酸水平正常组，但差异无统计学意义（P〉0．05）。④以尿酸水平为因变量进行多元回归分析。结果显示SBP、DBP、TC、TG、LDL—C、HDL—C为血尿酸影响因素（P〈0．05）。结论高尿酸血症与肥胖、血脂异常、高血压等有密切关系，可增加心血管疾病的危险性，但与糖尿病之间的相关性尚需进一步研究。

The investigation of disease rates and cardiovascular risk factors related in elderly people with hyperuricemia

Objective To study the rates of hyperuricemia in elderly people in Shengzhou area,and analysis the relationship between related cardiovascular risk factors and hyperuricemia.Methods The blood glucose,blood pressure,blood fat,body mass index and many kinds of cardiovascular risk factors of 1 281 cases of more than 60 years old people with hyperuricemia disease were epidemiology investigated.Results ①The older population of this community hyperuricemia disease prevalence was 18.5%.②smoking rate and alcohol consumption rates and high blood pressure and coronary heart disease of the hyperuricemia group were higher than blood uric acid levels normal group,comparing statistical ignificance(P < 0.05),Stroke and diabetes were higher than blood uric acid levels normal group,but there were no statistically significant difference(P >0.05).③ The levels of TG,TC,SBP,DBP and LDL-C of hyperuricemia group were significantly higher than the blood uric acid levels normal group,and comparing statistical significance(P < 0.05).HDL-C level was significantly lower than the blood uric acid levels normal group,and comparing statistical significance(P < 0.05).BMI and FPG level were higher than blood uric acid levels normal group,but is not statistically significant difference(P > 0.05).④ To define uric acid levels as the dependent variable for multiple regression analysis.The result shows,the TC,SBP,DBP,TG,LDL-C,HDL-C were factors for blood uric acid(P < 0.05).Conclusion hyperuricemia and obesity,dyslipidemia,hypertension have close relations,can increase the risk of cardioascular disease.but the correlation between hyperuricemia and diabetes need to be studied.