eNOS基因多态性与糖尿病肾病易感性相关关系

目的探讨eNOS基因多态性与糖尿病肾病易感性的相关关系。方法选择病程大于10年的88例南方汉族2型糖尿病（T2DM）患者为研究对象。将尿微量白蛋白排泄率（UAER）〉20μg／mL归入糖尿病肾病（DN）组，将UAER≤20μg／mL归入对照组，比较两组患者的年龄、性别构成、血压、血脂、血糖、C肽、糖化血红蛋白等传统危险因素的差异，并进行eNOS基因多态性分析。结果①两组患者在性别构成、年龄、糖尿病病程、吸烟及高血压比例、收缩压、舒张压、体重指数、空腹血糖、餐后2h血糖、空腹C肽、餐后2hC肽、糖化血红蛋白、胆固醇和甘油三酯等方面比较，差异无统计学意义（P〉0．05）。②DN组GT基因型及T等位基因显著高于对照组，差异有统计学意义（P〈0．05）。结论eNOS基因GT基因型及T等位基因是DN是易感因素。

The correlation of eNOS gene polymorphism and susceptibility to diabetic nephropathy

Objective To explore the relationship between gene polymorphism in chromosome eNOS and susceptibility to diabetic nephropathy.Methods A total of 88 patients from south of China were included in the study,49 of whom were divied into the diabetic nephropathy(DN)group because of the urinary albumin excretion rate(UAER) >20 μg/mL,and 39 of who were divied into the control group because of the UAER≤20 μg/mL.We detected the traditional risk factors,and the gene polymorphism in chromosome eNOS by PCR-RFLP method.Results There was no significant difference in the traditional risk factors(P > 0.05).The TG genetype and T allete in the DN group were significantly more than that in the control group.Conclusion The TG genetype and T allete in chromosome eNOS probably are the predisposing factors to diabetic nephropathy.