急性冠脉综合征患者血清hs-CRP和IL-10水平变化及临床意义

目的检测急性冠脉综合征（ACS）患者血清超敏C反应蛋白（hs—CRP）和白细胞介素10（IL-10）水平，并探讨其变化与斑块稳定性的关系。方法ACS患者29例，其中急性心肌梗死（AMI）16例，不稳定型心绞痛（UAP）13例，稳定型心绞痛（SAP）患者20例，对照组20例，用双抗体夹心酶联免疫吸附试验（ELISA）法测定血清hs—CRP和IL-10水平。结果ACS组患者血清hs—CRP和IL-10水平均高于SAP组和对照组（P〈0．05），SAP组血清hs—CRP和IL-10水平虽高于对照组，但比较差异无显著性（P〉0．05）；ACS组患者血清hs—CRP／IL-10比值高于SAP组和对照组（P〈0．05），SAP组血清hs—CRP／IL-10比值与对照组比较差异无显著性（P〉0．05）；ACS患者血清hs—CRP水平和IL-10水平呈正相关（r=0．73，P〈0．05）。结论ACS患者血清hs—CRP和IL-10水平均升高，hs—CRP／IL-10比值增大，示有炎症反应并参与动脉粥样硬化斑块形成，炎症反应不平衡可能与ACS患者斑块的不稳定有关。

Changes and its clinical significance of serum hs-CRP and IL-10 levels in patients with acute coronary syndromes

Objective To determinate serum high-sensitive C-reactive protein(hs-CRP)and interleukin-10(IL-10)levels in patients with acute coronary syndromes(ACS) and explore their relation with plaques stability.Methods Twety-nine patients with ACS,including 16 patients with acute myocardial infarction(AMI),13 patients with unstable angina pectoris(UAP).The study also included 20 patients with stable angina pectoris(SAP) and 20 cases of control subjects.The serum hs-CRP and IL-10 levels were measured by double antibody enzyme linked immunosorbent assay(ELISA).Results ACS patients exhibited higher serum levels of hs-CRP and IL-10 as compared with those of SAP patients and controls(P < 0.05),SAP group serum hs-CRP and IL-10 levels were higher than that of the control group,but no significant difference compared(P > 0.05);The ratio of serum hs-CRP/IL-10 in ACS group of patients was higher than SAP group and control group(P < 0.05),The ratio of serum hs-CRP/IL-10 in SAP group compared with control group was no significant differences(P > 0.05);There was positive correlation between serum hs-CRP and IL-10 levels in patients with ACS(r = 0.73,P <0.05).Conclusion The serum levels of hs-CRP and IL-10 raise,the ratio of hs-CRP/IL-10 increase in ACS patients,which showed that it have some inflammation in ACS patients,and this inflammation participate in atherosclerotic plaque formation,and Inflammation imbalance may have some relation with the instability of plaques in ACS patients.