兰索拉唑联合多潘立酮和胶体果胶铋治疗胆汁反流性食管胃炎74例疗效观察

目的探讨兰索拉唑、多潘立酮和胶体果胶铋三者联合治疗胆汁反流性胃食管炎与兰索拉唑、莫沙必利、磷酸铝凝胶三者伍用治疗胆汁反流性胃食管炎的临床疗效差异。方法将180例经内镜确诊的反流性食管炎患者随机分为观察组兰索拉唑（30mg，qd），多潘立酮（10mg，tid），胶体果胶铋（150mg，qid）]和对照组『兰索拉唑（30mg，qd），莫沙必利（10mg，f谢），磷酸铝凝胶（20gqid）]，疗程6周。记录治疗前和用药期间烧心、反酸、嗳气、胸骨后疼痛等症状的变化及有无不良反应出现。于疗程结束时和疗程结束后的3、6、12个月行胃镜复查，并记录上消化道出现的症状。最终有167例完成了整个疗程，143例完成了各阶段随访（其中观察组74例、对照组69例）。结果二组均能有效缓解反流性食管炎的临床症状，但观察组总有效率高于对照组，复发率低于对照组，组间差异有统计学意义（P〈0．05），且副作用和费用相对较低。结论兰索拉唑、多潘立酮和胶体果胶铋三者联合治疗反流性食管炎的临床总有效率较兰索拉唑、莫沙必利、磷酸铝凝胶三者联合更好，且复发率低，值得临床推广使用。

Lansoprazole combined with Domperidone and Colloidal Bismuth Pectin treatment of bile reflux esophageal gastritis,74 cases of efficacy

Objective To Investigate the lansoprazole,domperidone and colloidal bismuth pectin combination therapy of bile reflux gastric esophagitis with lansoprazole,mosapride,aluminum phosphate gel treatment of the combination therapy g bile reflux gastric esophagitis differences in clinical efficacy.Methods 140 cases diagnosed by endoscopic bile reflux gastric esophagitis were randomly divided into two groups: lansoprazole(30 mg,qd),domperidone(10 mg,tid),colloidal bismuth pectin(150 mg,qid);control group,lansoprazole(30 mg,qd),mosapride(10 mg,tid);aluminum phosphate gel(20 g,qid),mosapride(10 mg,tid);treatment for 6 weeks.Recorded before treatment and during treatment of heartburn,acid reflux,belching,chest pain and other symptoms of change and the presence of adverse reactions occur.At the end of treatment and after treatment of 3 months,6 months,12 months endoscopy review,and record of upper gastrointestinal symptoms.The final 167 patients completed the entire course of treatment,143 patients completed the stages of follow-up(in which the observation group of 74 cases,69 cases of the control group).Results Two groups can effectively relieve bile reflux gastric esophagitis symptoms,but the observation group was 10.63% higher efficiency,the recurrence rate 13.19% lower than the control group,statistically significant difference between the groups(P < 0.05),and side effects and relatively low costs.Conclusion Lansoprazole,domperidone and colloidal bismuth pectin three combined treatment of bile reflux gastric esophagitis total effective than the three combined treatment of lansoprazole,mosapride,aluminum phosphate gel better,and the recurrence rate worthy of clinical use.