| VEGF在人脑AVMs中的表达分析 |
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| 引用本文： | 王建清,孙青芳,卞留贯,赵卫国,沈建康,张天锡. VEGF在人脑AVMs中的表达分析[J]. 神经疾病与精神卫生, 2003, 3(3): 175-177 |
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| 作者姓名： | 王建清 孙青芳 卞留贯 赵卫国 沈建康 张天锡 |
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| 作者单位： | 1. 221100,上海第二医科大学瑞金医院集团闵行医院神经外科
2. 上海瑞金医院神经外科 |
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| 摘 要： | 目的 分析VEGF在人脑AVMs中的表达。方法 14例AVMs行显段外科手术切除AVMs和AVMs周围脑组织、8例正常脑血管标本，分别提取总RNA和4％PFA—PBS固定石蜡包埋、原位杂交、RNA狭缝斑点杂交检测VEGF在脑AVMs中的改变。结果 VEGFmRNA弥散地分布于血管的各层组织和AVMs周围脑组织中，与正常脑血管相比，AVMs、AVMs周围脑组织VEGFmRNA表达增高。结论VEGF参与脑AVMs的发生发展。
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| 关 键 词： | VEGF 人脑 AVMs 表达 血管内皮生长因子 脑血管畸形 |
| 文章编号： | 1009-6574(2003)03-0175-03 |
| 修稿时间： | 2003-01-11 |
The Analysis of VEGF Expression in Brain AVMs |
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| Wang Jianqing,Sun Qing fang,BianLiuguan,et al.. The Analysis of VEGF Expression in Brain AVMs[J]. Nervous Diseases and Mental Health, 2003, 3(3): 175-177 |
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| Authors: | Wang Jianqing Sun Qing fang BianLiuguan et al. |
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| Abstract: | Objective To analyse the VEGF expression in brain AVMs. Methods By Microneuro-surgery operation the AVMS and the surrounding brain tissue were removed in 14 patients. All samples and eight normal brain tissues were fixed in 4 % PFA - PBC, then embedded in paraffin. The RNA and AVMs were detected in situ hybridization,RNA slot blot. Results VEGF mRNA distributed every level tissue of vessels and the surrounding brain tissue of AVMs. Compared with normal brain vessels, the VEGF expression was higher in AVMs and the surrounding tissue than in the normal brain. Conclusions VEGF might take part in the pathogenesis of cerebral AVMs development and growth. |
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| Keywords: | VEGF AVMs |
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