直肠癌新辅助化疗前后血清 VEGF 与 VEGFR -2 的变化及临床意义

目的探讨直肠癌患者新辅助化疗前后血清血管内皮生长因子（VEGF）及血管内皮细胞生长因子受体2（VEGFR-2）水平的变化及临床意义。方法应用ELISA法检测45例直肠癌患者（化疗组）新辅助化疗前后血清VEGF与VEGFR-2的表达水平，并与45例正常健康人（对照组）作比较。结果化疗组新辅助化疗前血清VEGF、VEGFR-2水平均明显高于对照组（P均〈0．01）。新辅助化疗8周后，完全缓解及部分缓解组VEGF、VEGFR-2表达水平均较化疗前明显降低（P均〈0．05），降低程度明显高于稳定组（P均〈0．01）；稳定组化疗后VEGFR、VEGF-2较化疗前显著降低（P均〈0．05）；进展组化疗后VEGF、VEGFR-2水平均较化疗前显著升高（P均〈0．05）。化疗前VEGFR水平与VEGF-2表达呈正相关关系（P〈0．01）。结论直肠癌患者血清中VEGFR、VEGF-2均高表达。测定直肠癌患者新辅助化疗前后血清VEGFR、VEGF-2水平的变化有助于临床判断化疗效果及肿瘤进程。

Clinical significance of the serum levels of VEGF and VEGFR -2 in patients with rectal cancer before and after neoadjuvant chemotherapy

Objective It is to approach the clinical significance of the serum level changes of vascular endothelial growth factor （VEGF） and vascular endothelial growth factor receptor - 2 （ VEGFR - 2） in patients with rectal cancer before and after neoadjuvant chemotherapy. Methods The serum levels of VEGF and VEGFR - 2 of 45 cases with colon carcinoma patients were detected by ELISA and which were compared with those in 45 healthy people. Results The serum levels of VEGF and VEGFR- 2 in colon carcinoma patients before neoadjuvant chemotherapy were significantly higher than those in the healthy people （P 〈0.01 ）. The serum levels in complete remission and partial remission patients in eight-weeks post-chemotherapy were significantly lower than those in pre-chemotherapy （ P 〈 0.05 ） , and lower levels were obviously higher than the stable group （ P 〈 0.01 ）. The VEGF, VEGFR - 2 levels in the stable treatment patients were also lower than that of before neoadju- vant chemotherapy （ P 〈 0.05 ）. The serum levels in the progression group were markedly higher than those of before treatment （ P 〈 0.05 ）. There was positive correlation in serum levels of VEGF and VEGFR - 2 before chemotherapy （ P 〈 0. 01 ）. Con- clusion The serum levels of VEGF and VEGFR - 2 in rectal cancer are high expression. The determination of VEGFR and VEGFR - 2 levels changes in patients with rectal cancer before and after neoadjuvant chemotherapy is helpful to determine the effecl of chemotherapy and the progression of tumor.