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均匀设计法优选虎杖提取工艺
引用本文:赵瑞芝,袁小红,丘小惠,朱尚红.均匀设计法优选虎杖提取工艺[J].中国医院药学杂志,2006,26(1):17-18.
作者姓名:赵瑞芝  袁小红  丘小惠  朱尚红
作者单位:广州中医药大学第二临床医学院中药制剂学实验室,广东,广州,510120
基金项目:广东省教育厅科研项目;广州中医药大学校科研和教改项目
摘    要:目的:筛选虎杖提取工艺,为益脑脉制剂工艺改革提供依据。方法:以虎杖中主要有效成分大黄素,白藜芦醇,白藜芦醇苷以及浸膏得率为指标,以均匀设计实验考察了乙醇浓度、溶媒量、提取时间、提取次数等对效果的影响。结果:60%乙醇、14倍量提取1.5h,提取液中3种有效成分含量均较高,浸膏得率较低。结论:简单易行,适合工业化生产。

关 键 词:虎杖  白藜芦醇  白藜芦醇苷  大黄素  薄层扫描
文章编号:1001-5213(2006)01-0017-02
收稿时间:2004-08-30
修稿时间:2004年8月30日

Optimization of extraction procedure of Polygonum cuspidatum by uniform-design
ZHAO Rui-zhi,YUAN Xiao-hong,QIU Xiao-hui,ZHU Shang-hong.Optimization of extraction procedure of Polygonum cuspidatum by uniform-design[J].Chinese Journal of Hospital Pharmacy,2006,26(1):17-18.
Authors:ZHAO Rui-zhi  YUAN Xiao-hong  QIU Xiao-hui  ZHU Shang-hong
Institution:The Center Laboratory of The Traditional Chinese Medicine Hospital of Guangdong Province, Guangdong Guangzhou 510120,China
Abstract:OBJECTIVE To optimize the extraction procedure of Polygonum cuspidatum,in order to provide the basis of preparation technology reform of YI NAO MAI capsules.METHODS The components of emodin,resveratroland polydatin were used as the marker,the optimum uniform-design was used to optimize the extraction procedure.RESTLUTSThe best extraction procedure was as follows: adding 14 times 60% ethanol,decocting once for 1/5 h.CONCLUSION The optimized procedure is simple and easy to do,it is suitalle for industrial production.
Keywords:Polygonum cuspidatum  emodin resveratrol    polydatin  TLC
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