| 胆汁淤积型药物性肝病92例临床研究 |
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| 引用本文： | 高得勇,李永强,王迎迎,吴剑琴,夏利萍,陆国庆. 胆汁淤积型药物性肝病92例临床研究[J]. 泰山医学院学报, 2011, 32(4): 270-272 |
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| 作者姓名： | 高得勇 李永强 王迎迎 吴剑琴 夏利萍 陆国庆 |
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| 作者单位： | 上海交通大学附属第一人民医院松江分院感染科,上海,201600 |
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| 摘 要： | 目的分析总结近年来本院发生胆汁淤积型药物性肝病的病因及熊去氧胆酸（UDCA）治疗本病的疗效。方法回顾分析近3年来各种药物致胆汁淤积型药物性肝病92例,探讨胆汁淤积型药物性肝病的病因及临床特点;比较分析了采用保肝降酶加UDCA（750 mg/d）治疗（A组=62例）及未应用UDCA治疗（B组=30例）的恢复情况,观察2组间临床症状、体征的改善和肝功能生化指标。结果引起胆汁淤积型药物性肝病的药物主要有中草药（22.83%）、抗肿瘤药（17.39%）、抗结核药（16.30%）和抗生素（13.04%）。经治疗后2组患者临床症状、体征均有明显改善;治疗前后的TBil、DBil、GGT差值两组比较差异有统计学意义（P=0.0002,P=0.0007,P=0.0009）。结论引起胆汁淤积型药物性肝病的病因是多样的,加用UDCA治疗胆汁淤积型药物性肝病疗效显著。
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| 关 键 词： | 胆汁淤积 药物性肝病 临床研究 |
Retrospective clinical analysis of 92 cases of cholestasis-type drug-induced liver disease |
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| GAO De-yong,LI Yong-qiang,WANG Ying-ying,WU Jian-qin,XIA Li-ping,LU Guo-qing. Retrospective clinical analysis of 92 cases of cholestasis-type drug-induced liver disease[J]. Journal of Taishan Medical College, 2011, 32(4): 270-272 |
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| Authors: | GAO De-yong LI Yong-qiang WANG Ying-ying WU Jian-qin XIA Li-ping LU Guo-qing |
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| Affiliation: | GAO De-yong LI Yong-qiang WANG Ying-ying WU Jian-qin XIA Li-ping LU Guo-qing(Dept.of Infectious Diseases,Songjiang Hospital Affiliated to Shanghai FirstPeople's Hospital,Shanghai Jiaotong University,Shanghai 201600,China) |
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| Abstract: | Objective: To investigate the etiology and incidence of cholestasis-type drug-induced liver disease and to observe the efficacy of ursodeoxycholic acid(UDCA)in the treatment in our hospital.Methods: We investigated the causes of 92 cases and incidence of cholestasis-type drug-induced liver disease caused by some medicines in 92 cases using retrospective methods.The 92 cases were divided into the two groups: one of the treatment with liver-protecting and transaminase lowering treatment together with UDCA(750... |
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| Keywords: | cholestasis drug-induced liver disease clinical analysis |
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