18F-FDG accumulation in atherosclerosis: use of CT and MR co-registration of thoracic and carotid arteries |
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Authors: | Kumiko Okane Masanobu Ibaraki Hideto Toyoshima Shigeki Sugawara Kazuhiro Takahashi Shuichi Miura Eku Shimosegawa Junichiro Satomi Keishi Kitamura Tomohiko Satoh |
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Institution: | (1) Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels–Akita,, Akita, Japan;(2) Department of Neurosurgery, Research Institute for Brain and Blood Vessels–Akita,, Akita, Japan;(3) Research and Development Department, Medical Systems Division, Shimadzu Corporation, Kyoto, Japan |
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Abstract: | Purpose The purpose of this study was to depict 18F-fluoro-2-deoxy-D-glucose (FDG) accumulation in atherosclerotic lesions of the thoracic and carotid arteries on CT and MR images by means of
automatic co-registration software.
Methods Fifteen hospitalised men suffering cerebral infarction or severe carotid stenosis requiring surgical treatment participated
in this study. Automatic co-registration of neck MR images and FDG-PET images and of contrast-enhanced CT images and FDG-PET
images was achieved with co-registration software. We calculated the count ratio, which was standardised to the blood pool
count of the superior vena cava, for three arteries that branch from the aorta, i.e. the brachial artery, the left common
carotid artery and the subclavian artery (n=15), for atherosclerotic plaques in the thoracic aorta (n=10) and for internal carotid arteries with and without plaque (n=13).
Results FDG accumulated to a significantly higher level in the brachial artery, left common carotid artery and left subclavian artery
at their sites of origin than in the superior vena cava (p=0.000, p=0.000 and p=0.002, respectively). Chest CT showed no atherosclerotic plaque at these sites. Furthermore, the average count ratio of thoracic
aortic atherosclerotic plaques was not higher than that of the superior vena cava. The maximum count ratio of carotid atherosclerotic
plaques was significantly higher than that of the superior vena cava but was not significantly different from that of the
carotid artery without plaque.
Conclusion The results of our study suggest that not all atherosclerotic plaques show high FDG accumulation. FDG-PET studies of plaques
with the use of fused images can potentially provide detailed information about atherosclerosis. |
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Keywords: | FDG-PET CT MRI Image fusion Atherosclerosis |
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