An Epstein-Barr virus-producer line Akata: Establishment of the cell line and analysis of viral DNA |
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| Authors: | Kenzo Takada Kenichi Horinouchi Yasushi Ono Takao Aya Toyoro Osato Motoo Takahashi Shinichi Hayasaka |
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| Affiliation: | (1) Department of Microbiology, Nihon University School of Medicine, Tokyo, Japan;(2) Department of Virology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan;(3) First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan |
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| Abstract: | An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q-; 14q+), and was derived from the tumor cell. Akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells should be useful as a source of EBV. |
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| Keywords: | Epstein-Barr virus Burkitt's lymphoma B-cell line virus production viral DNA Southern analysis |
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