| 化疗药物与肿瘤细胞环氧化酶-２表达及多药耐药之间相互关系的研究进展 |
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| 引用本文： | 张梦曦,顾康生.化疗药物与肿瘤细胞环氧化酶-２表达及多药耐药之间相互关系的研究进展[J].临床肿瘤学杂志,2009,14(4):377-380. |
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| 作者姓名： | 张梦曦 顾康生 |
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| 作者单位： | 1安徽医科大学第一附属医院肿瘤科 |
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| 摘 要： | 环氧化酶-２（ＣＯＸ-２）是体内前列腺素合成的关键酶之一，与肿瘤的发生发展密切相关，且与肿瘤多药耐药（ＭＤＲ）也存在关联性，影响肿瘤化疗疗效及转归。了解化疗药物对肿瘤细胞ＣＯＸ-２的影响及与ＭＤＲ之间的相互作用及调控关系，对于进一步明确ＭＤＲ形成机制及预防和逆转化疗所致ＭＤＲ有着重要的意义。
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| 关 键 词： | COX-2 多药耐药 化学治疗 肿瘤 |
| 收稿时间： | 2008-10-26 |
| 修稿时间： | 2009-01-06 |
The influence of chemotherapeutics upon the COX-2 of tumour cells and the interaction between chemotherapeutics and MDR |
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| ZHANG Meng-xi,GU Kang-sheng.The influence of chemotherapeutics upon the COX-2 of tumour cells and the interaction between chemotherapeutics and MDR[J].Chinese Clinical Oncology,2009,14(4):377-380. |
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| Authors: | ZHANG Meng-xi GU Kang-sheng |
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| Institution: | ZHANG Meng-xi,GU Kang-sheng.(Department of Oncology,the First Affliated Hospital,Anhui Medical University,Hefei 230022,China ) |
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| Abstract: | COX-2,one of the key enzymes in the prostaglandin synthesis,is not only closely related to the occurrence and development of tumor,but also has some relevance with MDR of tumor,affects the therapeutic effects and outcomes of tumor chemotherapy.To know the influence of chemotherapeutics upon the COX-2 of tumour cells and the interaction and regulation relationships between chemotherapeutics and MDR,is of great significance to further clarify the formation mechanism of MDR,and the prevent and reverse of the chemotherapy-induced MDR. |
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| Keywords: | COX-2 |
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