玛咖独行菜对卵巢切除术后大鼠血脂及骨质代谢的影响

目的利用雌激素低下动物模型,探讨玛咖独行菜(LepidiummeyemiiWalp,俗称Maca)对雌性大鼠体脂、性激素、骨代谢的影响。方法健康SD雌性大鼠进行卵巢切除术后根据体重随机分为模型组、雌激素组以及Maca低、中、高剂量组;另设未做卵巢切除术的假手术组作为对照组。雌激素组每天灌胃己烯雌酚(30μg/kgbw);Maca低、中、高剂量组每天分别灌胃Maca悬浊液0.3、0.6、1.8g/kg;假手术组和模型组每天灌胃蒸馏水。7周后测定各组大鼠体重、子宫和肾上腺重量,及血脂、性激素、骨代谢相关指标的水平。结果模型组显示卵巢切除术后大鼠体重快速增长,子宫、肾上腺重量降低,雌、孕激素及睾酮水平下降,血脂水平增高,血碱性磷酸酶水平升高(和假手术组相比,P<0.05)。相比之下,给予己烯雌酚的雌激素组血雌激素水平提高、子宫重量维持不变、体重过度增长得到改善(和模型组相比,P<0.05);Maca高剂量组大鼠的低密度脂蛋白胆固醇、甘油三酯和血碱性磷酸酶水平明显降低,骨钙素的作用增强(和模型组相比,P<0.05),但性激素分泌无显著变化。结论玛咖独行菜有助于改善卵巢切除术后血脂异常和骨质代谢。

Influence of Lepidium meyemii walp on lipid and bone mass in ovariectomized rats

Objective To observe the potential effects of Lepidium meyemii Walp (MACA) on body fat, sexual hormone, bone metabolism in post-ovariectomized rats. Method Healthy Sprague-Dawley rats were randomly divided into 6 groups: sham operated group, ovarieetomized model group(OVX), OVX + estrogen treated group(30μg/kg), OVX +Maca low dose treated gruup(0.3 g/kg), OVX + Maca middle dose treated group(0.6 g/kg) and OVX + Maca high dosetreated group( 1.8 g/kg). After 7 weeks treated the rats were sacrificed, the body weight, uterus and adrenal gland weightwere measured, the blood lipids, sexual hormone, bone metabolism were analyzed. Results In ovariectomized model group(OVX) the level of estrogen, progesterone, testosterone and the weigh of uterine and adrenal were decreased, thebody weight gain, serum lipid and the activities of alkaline phosphatase (ALP) were increased (compared with sham operated group, P < 0.01 ), though the change of femoral bone density and mineral content was not observed. The blood estrogen and BPG level were increased in OVX + MACA high dose treated group, and had less uterine weight loss and body weight gain, while, the triglyceride, LDL-C and ALP level were similar to sham operated group. Conclusion Dietary supplementation with Maca may have potential effects on prevention from postmenopausal lipid abnormality and bone metabolism via a different mechanism from estrogen.