县级医院药师下临床如何开展临床药学服务

目的：对牡丹皮中丹皮酚的提取工艺进行研究，考察超声辅助水蒸气蒸馏提取的效果，改进提取工艺。方法：采用中国药典HPLC方法测定丹皮酚的含量，系统比较蒸馏水用量、乙醇加入量和超声时间等3个主要因素，计算馏出液中丹皮酚的提取结果。结果：确定水蒸气蒸馏提取牡丹皮中丹皮酚的工艺为药材加10倍量蒸馏水，超声20min后，蒸馏，收集至蒸馏液不再浑浊时为止。结论：本工艺采用超声对药材进行预处理，可以极大的提高丹皮酚的提取效率，操作简单、成本低、毒性小，可用于丹皮酚的大规模制备。

Study of extraction technology of paeonol in Cortex Moutan

Objective:To study the extraction technology of paeonol from Cortex Moutan,and improve the extraction method of steam distillation with ultrasonic assistance.Methods:The paeonol was determined by HPLC method in Chinese Pharmacopeia 2005. The distilled water amount,alcohol addition amount and uhransonic time,meanwhile were conpared,the extraction amounts of paeonol in distillate were calculated.Results:The final affirmed method of paeonol extraction was ten times distilled water and transonic twenty minutes,then distill until the distillate was not turbid.Conclusion: The final method was pretreated by ultrasonic which could increase the extraction efficiency greatly,and has the advantages of simple,economic and low toxicity,also can be used in the large-scale prep- aration of paeonol.