| Bmi1基因在干细胞和肿瘤发生中的作用 |
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| 引用本文： | 张锐,刘超. Bmi1基因在干细胞和肿瘤发生中的作用[J]. 国际肿瘤学杂志, 2009, 36(11). DOI: 10.3760/cma.j.jssn.1673-422X.2009.11.002 |
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| 作者姓名： | 张锐 刘超 |
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| 作者单位： | 中山大学附属第二医院南院综合外科,广州,510000;中山大学附属第二医院南院综合外科,广州,510000 |
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| 摘 要： | 干细胞是一类具有自我更新能力并可向多种细胞、组织类型分化的细胞.Bmi1基因在维持干细胞的自我更新能力中起关键的作用.干细胞与很多肿瘤的发生有关.增强干细胞的自我更新能力可以改变干细胞的生物特性,进一步导致肿瘤的发生.
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| 关 键 词： | 干细胞 Bmil基因 肿瘤 |
Bmil gene in stem cells and tumorigenesis |
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| ZHANG-Rui,HU-Chao. Bmil gene in stem cells and tumorigenesis[J]. Journal of International Oncology, 2009, 36(11). DOI: 10.3760/cma.j.jssn.1673-422X.2009.11.002 |
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| Authors: | ZHANG-Rui HU-Chao |
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| Abstract: | Stem cells are characterized by the ability to renew themselves and differentiate into a di-verse range of specialized cell types.Bmi1 gene has been determined to play critical roles in the self-renewal of stem cells.Many of the tumor originated in stem cells.Enhanced self-renewal capability in stem/progenitor cells changes its biological characteristic and drives tumor initiation |
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| Keywords: | Stem cells Bmil gene Neoplasms |
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