我国五个人群血、尿营养性参数与血压关系的研究

随机选取住我国南域贵州威宁山区农民、北方河北石家庄工人与农民、舟山渔民和我国民旋中高血压患病率最低的彝族共467人(男,40～59岁),研究血、尿营养性参数—血压(BP)关系。各人群饮食习惯、血压水平互异。研究发现:(1)威宁汉、彝组心率、体量指数、血压最低。(2)血、尿营养性参数值大致与各人群饮食习惯吻合。(3)尿Na、Ca、Ca/Mg、尿素氮及血胆固醇、总蛋白、白蛋白、尿酸在高血压(HT)组较高;而尿K较低。(4)从多因子回归及(或)判别分析,示尿Na、Na/K、Ca/Mg与BP正相关,而K、Mg负相关;血清白蛋白、总蛋白、胆固醇、甘油三酯、尿酸则与BP正相关。结果提示高Na(Ca)可能升压、而高K(Mg)可能降压;血蛋白—BP关系难以用高血压时,因血液浓缩继发引起来解释;无论摄入高动物或植物蛋白均可能升压;高血脂可能是高血压的一个危险因子,不一定继发于两血压。在设计我国高血压一级预防战略方案时应予考虑。

RELATIONSHIP BETWEEN BLOOD AND URINE NUTRITIONAL PARAMETERS AND BLOOD PRESSURE AMONG FIVE POPULATION GROUPS IN CHINA

Five population groups, including farmers living in Veining (a cold hilly southern county), farmers and labourers in Shijiazhuang (a northern district), coastal fishermen in Zhoushan and "Yi" nationality farmers in Veining (where the incidence of hypertension is very low in China) were selected randomly (467 male subjects, 40-59 years old) to explore nutritional parameters-BP relationships. The results showed; (1) Pulse rate, QI and BP were lowest in Veining "Han" and "Yi" nationality groups. (2) Values of blood and urine nutritional parameters were in close accord with the diet customs of the different population groups. (3) Urine Na, Ca, Ca/Mg, urea nitrogen and serum cholesterol, total protein, albumin, uric acid were higher, while urine K was lower in hypertensives. (4) Urine Na, Na/K, Ca/ Mg and serum albumin, total protein, cholesterol, triglyceride, uric acid levels correlated positively, while K inversely with BP on multivariate stepwise regression and/or discrimination analyses. These results suggested high Na (Ca)-intake might be hypertensive, while high K(Mg)-intake an-tihypertensive, the serum protein - BP relationship could not be ascribed as a secondary effect of hemoconcentration in hypertension; a high protein intake, regardless of nature, could be hypertensionogenic; hyperlipidemia seemed to be a risk factor of hypertension, not being the secondary consequence to high BP. In designing a strategic protocol for primary prevention of hypertension, the above should be given due consideration.