Pediatric B‐Cell Lymphoma With Lymphoblastic Morphology,TdT Expression,MYC Rearrangement,and Features Overlapping With Burkitt Lymphoma |
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| Authors: | Jessica Meznarich MD Rodney Miles MD PhD Christian N. Paxton PhD Zeinab Afify MD |
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| Affiliation: | 1. Division of Hematology‐Oncology, Department of Pediatrics, School of Medicine and Primary Children's Hospital, University of Utah, Salt Lake City, Utah;2. Department of Pathology, University of Utah and ARUP Laboratories, Salt Lake City, Utah;3. ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah |
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| Abstract: | Burkitt lymphoma (BL) and B‐lymphoblastic lymphoma are subtypes of pediatric non‐Hodgkin lymphoma with different presenting features, treatment, and outcomes. This case report documents a 5‐year‐old female who presented with B‐cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. Genomic microarray analysis identified a gain on the long arm of chromosome 1 without other definitive changes. She was treated according to a BL protocol and remains in remission 16‐months after initial diagnosis. |
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| Keywords: | B‐lymphoblastic lymphoma Burkitt lymphoma MYC rearrangement |
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