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Primary Effusion Lymphoma (PEL)‐Like Lymphoma in a Child With Congenital Immunodeficiency |
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| Authors: | Mohamed Abdelhaleem MD PhD FRCP Gino R Somers MBBS PhD FRCPA Chaim Roifman MD FRCP FCACB Stanley Read MD PhD FRCPC Oussama Abla MD |
| Institution: | 1. Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada;2. Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada;3. Division of Immunology and Allergy, The Hospital for Sick Children, Toronto, Ontario, Canada;4. Division of Infectious Diseases, The Hospital for Sick Children, Toronto, Ontario, Canada |
| Abstract: | Primary effusion lymphoma (PEL) is a rare lymphoma that occurs more frequently in immunocompromised adults and has a poor survival. We report a 9‐year‐old female with combined immunodeficiency with an Epstein–Barr virus positive/human herpes virus 8 negative PEL‐like lymphoma. The treatment with systemic chemotherapy for non‐Hodgkin lymphoma, zidovudine, and interferon‐α failed to control disease progression. This is the first reported pediatric case of PEL‐like lymphoma. Increased diagnostic awareness and more effective treatment strategies are needed for this rare lymphoma. |
| Keywords: | children EBV lymphoma primary effusion |