纳洛酮治疗急性胰腺炎的临床疗效

目的探讨纳洛酮治疗急性胰腺炎的疗效。方法急性胰腺炎患者共44例,分为纳洛酮组与对照组,纳洛酮组每日静脉输注纳洛酮4mg加入5%葡萄糖溶液250ml中,其余常规治疗同对照组,观察血、尿淀粉酶及C反应蛋白(CRP)水平变化及临床症状纳络酮组改善程度。结果临床症状纳洛酮组较对照组恢复稍快,但无统计学差异;纳洛酮组治疗后第1、3、5、7天血淀粉酶水平明显低于对照组(P<0.05),尿淀粉酶水平于治疗后第1、5、7天及第2、3天较对照组明显降低(P<0.05,P<0.01),恢复到正常水平较对照组提前;纳洛酮组CRP水平在治疗前,治疗后3天开始有显著差别(P<0.01),对照组治疗前、后无明显差别(P>0.05)。结论静脉应用纳洛酮有助于急性胰腺炎的炎症恢复。

Clinical efficacy of Naloxone in treating acute pancreatitis

Objective To evaluate the efficacy of the naloxone in treating acute pancreatitis.Methods 44 patients with acute pancreatitis were divided into control group and naloxone group.Naloxone group was administrated intravaneously with 4 mg naloxone fused in 250 ml of 5% glucose.The amylase in urine and blood species and c reaction protein were observed.Results After treatment the amylase of serum was lower at the first,third,fifth,and seventh days than those of control group(P<0.05),the urine amylase was decreased apparantly and recovered to normal more rapidly than that of control group(P<0.05).C reaction protein was significantly different in naloxone group after treatment but not different in control group(P>0.05).Conclusion Intravenous administration of naloxone may contribute to the recovery of acute pancreatitis.