匹多莫德联合玉屏风颗粒治疗儿童反复呼吸道感染疗效观察及对机体免疫功能的影响

目的：观察匹多莫德与玉屏风颗粒联合应用，治疗儿童反复呼吸道感染的疗效及对机体免疫功能的影响。方法：选取90例符合入组标准的反复呼吸道感染患儿，按就诊时间分为对照组和治疗组各45例，对照组在急性感染期给予抗感染及对症治疗，在非急性感染期加强护理，避免受凉，只单独匹多莫德用药；治疗组在对照组基础上给予匹多莫德联合玉屏风颗粒口服，总疗程3个月，随访6个月，随访期间统计复发次数。进行两组临床疗效评判，同时检测两组患儿在治疗前、疗程结束后外周血，淋巴细胞亚群的表达水平及免疫球蛋白的含量。结果：治疗组总有效率为91．11％，明显高于对照组80．00％，两组比较差异有统计学意义（P〈0．05）；疗程结束后，治疗组血清IgA、IgG、IgM及外周血T细胞亚群CD3^＋、CD4^＋、CD8^＋、CD4^＋／CD8^＋较对照组升高，而外周血，细胞亚群CD8^＋较对照组下降，差异有统计学意义（P〈0．05）。结论：匹多莫德联合玉屏风颗粒能提高反复呼吸道感染患儿免疫功能，减少呼吸道感染的再发次数，减轻临床症状。

Clinical observation and influence on immune function of pidotimod combined with Yupingfeng power for children with recurrent respiratory tract infection

Objective： To observe the combined application of pidotimod combined with Yupingfeng power in the treatment of children with recurrent respiratory tract infection and its influence on immune function. Methods： 90 qualified children with recurrent respiratory tract infection were selected and divided into a control group and a treatment group according to the visiting time, 45 cases in each group. The cases in the control group were given anti-infection treatment and therapy according to symptoms in the acute infection period and given intensified nursing in non-acute period with pidotimod; while the cases in the treatment group were given pidotimod combined with Yupingfeng power on the basic of treatment for the control group. The total course was 3 months but patients were followed by 6 months and recurrence times were recorded. The curative efficacy of the two groups were judged, meanwhile, the expression levels in peripheral blood T lymphocyte subsets and content ofimmunoglobulins of the children before and after treatment were tested. Results ： The total effective rate of the treatment group was 91.11%, obviously higher that that of the control group 80.00%, and the difference was statistically significant （P〈0.05）. After treatment, serum IgA, IgG, IgM and peripheral blood T cell subsets CD3^＋. CD4^＋, CD8^＋. CD4^＋/CD8^＋ in the treatment group are higher than the control group, but peripheral blood T cell subsets CD8^＋ declines compared with the control group. The difference was statistically significant （P〈0.05）.Conclusions ： Pidotimod combined with Yupingfeng power can improve the immune function of children with recurrent respiratory tract infection and reduce the recurrent respiratory infections and clinical symptoms.