益胃丸系列药品对慢性萎缩性胃炎大鼠模型干预的实验研究 |
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引用本文: | 孙林. 益胃丸系列药品对慢性萎缩性胃炎大鼠模型干预的实验研究[J]. 中医临床研究, 2014, 0(18): 73-75 |
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作者姓名: | 孙林 |
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作者单位: | 甘肃省庆阳市中医医院,甘肃庆阳745000 |
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基金项目: | 庆阳市科技局科技支撑项目,项目编号:sh2011-32. |
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摘 要: | 目的:探讨益胃丸1号(温中益胃丸)、2号(舒肝益胃丸)药物治疗慢性萎缩性胃炎(CAG)的作用机理。方法:设正常组、模型组、维酶素组以及益胃丸1号、2号大、小剂量治疗组,采用100μg/m1甲基硝基亚硝基胍(MNNG)、2%水杨酸钠和30%酒精等综合方法进行模型复制,3个月制成大鼠CAG模型。观察各组大鼠模型治疗后胃酸、胃蛋白酶活性及血清胃泌素(Gas)含量。结果:治疗30d后,益胃丸高剂量组及维酶素组均不同程度的升高大鼠模型胃酸、提高胃蛋白酶活性、增加血清胃泌素含量(P〈0.05或P〈0.01)。结论:益胃丸1号、2号对CAG的干预机理可能是通过升高胃酸、提高胃蛋白酶活性、增加血清胃泌素含量来实现。
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关 键 词: | 温中益胃丸 舒肝益胃丸 萎缩性胃炎 大鼠模型 实验研究 |
Study of experimental intervention on rat models with chronic atrophic gastritis by Yiwei pills and series of medicine |
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Abstract: | Objective: To investigate the mechanism of Yiwei pills No. 1 (Wenzhong Yiwei pills), No. 2 (Shugan Yiwei pills) in the treatment of chronic atrophic gastritis (CAG). Methods: The normal group, model group, Weimeisu group and Yiwei pills No. 1 and No. 2 small and high dose groups were set with 100μg/ml MNNG, 2% sodium salicylate and 30% alcohol for model, 3 months into the rat CAG model. The contents of gastric acid, pepsin activity and serum gastrin (Gas) of model rats were observed after treatment. Results: after 30 days treatment, the contents of gastric acid, pepsin activity and serum gastrin in Yiwei pills high dose group and Weimeisu group were increased (P〈0.05 or P〈0.01). Conclusion: The intervention mechanism of Yiwei pills No. 1 and No. 2 is realized through increasing acid, activity of pepsin and content of serum gastrin. |
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Keywords: | Wenzhong Yiwei pills Shugan Yiwei pills Atrophic gastritis Rat model Experimental study |
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