心肌梗死后无症状心衰患者应用阿托伐他汀治疗的临床评价

目的：探讨心肌梗死后无症状心衰患者应用阿托伐他汀治疗的临床疗效.方法：选取我院收治的72例心肌梗死后无症状心衰患者作为研究对象,随机分为实验组（n=36）和对照组（n=36）,两组患者均在接受常规治疗的同时加用阿托伐他汀,对照组剂量为20mg/d,实验组剂量为40mg/d,对比两组患者的临床疗效.结果：实验组治疗后的NT-proBNP水平显著低于对照组（P〈0.05）;两组患者治疗前的LVEF、LVEDD、LVESD水平比较,无显著性差异（P〉0.05）;实验组治疗后的LVEDD、LVESD水平显著低于对照组,LVEF水平显著高于对照组,P〈0.05;实验组治疗后的6分钟步行距离明显高于对照组,P〈0.05,差异均具有统计学意义.结论：在心肌梗死后无症状心衰患者的临床治疗中,加用阿托伐他汀可有效改善患者心功能,减轻心室重构,40mg/d的给药剂量疗效更佳,值得推广应用.

Clinical evaluation on treatment of patients with no symptoms ofheart failure after myocardial infarction by atorvastatin

Objective： To investigate the clinical efficacy of atorvastatin in the treatment of in patients with heart failure but noclinical symptoms after myocardial infarction. Methods： 72 cases of myocardial infarction in our hospital with no symptoms of heart failureafter myocardial infarction as the research object were randomly divided into an experimental group （n=36） and a control group （n=36）,patients in the two groups were given conventional therapy plus atorvastatin at the same time, 20mg/d for the control group, theexperimental group at the dose of 40mg/d, and clinical effects were compared. Results： After treatment, the level of NT-proBNP in theexperimental group was significantly lower than that of the control group （P〈0.05）; compared two groups of patients before treatment, thelevels of LVEF, LVEDD, LVESD had, no significant difference （P〉0.05）; the level of LVEDD, LVESD in the experiment group aftertreatment was significantly lower than that of the control group, the LVEF level was significantly higher than that of control group, P〈 0.05;6 minute walking distance was significantly longer than that of the control group, P〈0.05, the differences were statistically significant.Conclusion： In the clinical treatment of patients without symptoms of heart failure in post myocardial infarction, the application ofatorvastatin can improve heart function of patients and reduce ventricular remodeling. the dose of 40mg/d administered is a better curativeeffect which is worthy of popularization and application.