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Diterpenoids from the stem barks ofCroton robustus
Authors:Nattaya?Ngamrojnavanich,Sorasaree?Tonsiengsom,Preecha?Lertpratchya,Sophon?Roengsumran,Songchan?Puthong,Amorn?Petsom  author-information"  >  author-information__contact u-icon-before"  >  mailto:amorn.p@chula.ac.th"   title="  amorn.p@chula.ac.th"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkom University, Bangkok 10330, Thailand.
Abstract:Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with ED50 of 9.2, 9.6 and 8.3, 9.1 microg/mL, respectively.
Keywords:Croton robustus  Trachyloban-19-oic acid  Trachyloban-19-ol  Poilaneic acid  Cytotoxic activity
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