Effects of hypoxia and isoflurane on liver blood flow: the role of adenosine |
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| Authors: | Cray S H Crawford M W Khayyam N Carmichael F J |
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| Affiliation: | 1Department of Anaesthesia, The Hospital for Sick Children and 2Department of Pharmacology, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada 3Present address: Birmingham Children’s Hospital NHS Trust, Steelhouse Lane, Birmingham B4 6NL, UK*Corresponding author |
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| Abstract: | We investigated the role of endogenous adenosine in mediatingthe effects of hypoxia and isoflurane on portal tributary bloodflow (PTBF) and hepatic arterial blood flow (HABF) in rats.Liver blood flows were determined using radiolabelled microspheres.Hypoxia resulting from the exposure of rats to an atmospherecontaining 15% oxygen for 30 min decreased PTBF (23%) (P<0.05)and cardiac index (15%) (P<0.05), and increased HABF (78%)(P<0.05). Isoflurane (1.4 vol%) increased HABF in both normoxicand hypoxic conditions but did not affect PTBF. The adenosinereceptor antagonist 8-phenyltheophylline attenuated the hypoxia-inducedincrease in HABF but did not affect that resulting from theadministration of isoflurane. In conclusion, in contrast tothe increase in HABF induced by hypoxia, that induced by isofluraneappears to be independent of endogenous adenosine. Br J Anaesth 2000; 86: 4257 |
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| Keywords: | liver, blood flow hypoxia anaesthetics volatile, isoflurane receptors, adenosine rat |
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