首页 | 本学科首页   官方微博 | 高级检索  
检索        


Local progression after radiofrequency ablation for pulmonary metastases
Authors:von Meyenfeldt Erik M  Prevoo Warner  Peyrot David  Lai A Fat Nathalie  Burgers Sjaak J A  Wouters Michel W  Klomp Houke M
Institution:Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Abstract:

BACKGROUND:

Local treatment for pulmonary metastases is considered to be a reasonable treatment option in patients with oligometastatic disease. Percutaneous radio frequency ablation (RFA) has been reported as an alternative to surgery. Results of RFA for local control of pulmonary metastases were evaluated.

METHODS:

All consecutive patients treated with RFA for pulmonary metastases (2004‐2009) were included. RFA was performed percutaneously under computed tomographic guidance. Follow‐up was scheduled at 1, 3, and 6 months after treatment and every 6 months thereafter. Major outcome parameters were local and any‐site progression, complications, and survival.

RESULTS:

Ninety pulmonary metastases were treated, in 46 patients at 65 sessions. Many patients had recurrent metastases after previous surgery (n = 36 of 46). Pneumothorax occurred in 34% (chest drain in 25%) and major complications in 6%. After median follow‐up of 22 months (range, 2‐65 months), 25 local progressions occurred after RFA; the 2‐year local progression rate per lesion was 35%. Overall survival at 3 years was 69%.

CONCLUSIONS:

Notwithstanding its relatively low morbidity, follow‐up after RFA for pulmonary metastases shows a considerable rate of local progression. The role of local ablation techniques for long‐term disease control in oligometastatic disease is discussed. Cancer 2011. © 2011 American Cancer Society.
Keywords:local progression  progression‐free survival  survival  metastasis  lung  local ablation techniques  radiofrequency ablation  oligometastatic disease
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号