The design and cytotoxic evaluation of some 1-aryl-3-isopropylamino-1-propanone hydrochlorides towards human Huh-7 hepatoma cells |
| |
Authors: | Mete Ebru Gul H Inci Cetin-Atalay Rengul Das Umashankar Sahin Ertan Gul Mustafa Kazaz Cavit Dimmock Jonathan R |
| |
Affiliation: | Department of Chemistry, Faculty of Sciences, Ataturk University, Erzurum, Turkey. ebru25@atauni.edu.tr |
| |
Abstract: | A series of 1-aryl-3-isopropylamino-1-propanone hydrochlorides 1 and a related heterocyclic analog 2 as candidate antineoplastic agents were prepared and the rationale for designing these compounds is presented. A specific objective in this study is the discovery of novel compounds possessing growth-inhibiting properties of hepatoma cells. The compounds in series 1 and 2 were prepared and their structures established unequivocally. X-ray crystallography of two representative compounds 1d and 1g were achieved. Over half of the compounds are more potent than 5-fluorouracil which is an established drug used in treating liver cancers. QSAR evaluations and molecular modeling studies were undertaken with a view to detecting some physicochemical parameters which govern cytotoxic potencies. A number of guidelines for amplification of the project have been formulated. |
| |
Keywords: | Anticancer drug design Huh‐7 cells Mannich bases Molecular modeling QSAR |
本文献已被 PubMed 等数据库收录! |