C-反应蛋白基因多态性与川崎病及其冠脉损伤的关系

目的]研究人类C反应蛋白（CRP）基因＋1059G/C、-757T/C多态性（SNPS）与川崎病（KD）及其冠状动脉损害（CAL）的关系.方法]通过基因测序对30名KD患儿和60名对照组儿童分别进行CRP基因＋1059G/C、-757T/C位点DNA序列测定.结果]①KD组CRP基因＋1059G/C多态性位点的GG、GC基因型分布频率和G、C等位基因频率、-757T/C多态性位点的TT、TC、CC基因型分布频率和T、C等位基因频率与正常对照组比较均无显著性差异（P均〉0.05）.②合并冠脉损伤者与无冠脉损伤组基因型分布频率和等位基因频率比较均无显著性差异（P〉0.05）.结论]CRP基因＋1059G/C、-757T/C基因多态性与川崎病及其冠状动脉损害的发生均无明显关联性.

Correlation Between Genetic Polymorphism of C-reactive Protein and Coronary Artery Lesion in Children with Kawasaki Disease

Objective] To investigate the relationship between the genetic polymorphisms of C-reactive protein（CRP） and coronary artery lesion（CAL） in children with Kawasaki disease（KD）. Methods]Gene sequence analysis was employed to confirm the mutational sites at ＋1059 and -757 of CRP in 30 cases of children with KD and 60 healthy children as control group. Results] As for the ＋1059G/C locus of CRP gene, there were no significant differences between genotype frequency of GG and GC types in KD and healthy controls（ P 〉0.05）. For the -757T/C locus of CRP gene, there were no significant differences between genotype frequency of TT, TC and CC types in KD and healthy controls（ P 〉0.05）. There were no significant differences in all the frequencies of genotype and allele of KD complicated with CAL and without CALf P 〉0. 05）. Conclusion] The polymorphisms of ＋1059G/C and -757T/C locus of CRP gene have no obvious association with the ; pathogenesis of KD and its complication of coronary artery lesion.