40例初治复治耐多药肺结核临床疗效分析

目的临床分析耐多药病例初治、复治抗结核治疗的效果。方法采取回顾性分析方法，选择耐多药病例40例，分初治、复治组，组间比较用χ^2检验。结果初治、复治组疗程结束时痰菌阴转率、肺部病灶吸收率、肺部空洞闭合及缩小率分别为：87．5％，66．7％；75．0％，62．5％；69．2％，54．5％。两组间无显著性差异。结论对初治耐多药病例应选择一线抗结核药物的标准方案，复治耐多药病例应根据既往抗结核药物用药史，药物敏感试验结果选择个体化治疗方案。

Analysis of clinical curative effect of initial treating and retreating 40 pulmonary multi-drug resistant tuberculosis patients

Objective To analyze the clinical curative effect of anti-tubercular treatment （ATT） in initial treating and retreating pulmonary multi-drug resistant tuberculosis （MDR-TB） patients. Methods 40 cases with pulmonary MDR-TB, selected and divided into initial treating group and retreating group, were retrospectively studied and the results were statistically analyzed by χ^2 test. Results The rates of TB-sputum negative reaction, absorption, cavity healing and diminution of the initial treating group and retreating group were respectively 87.5 % and 66. 7 %, 75.0% and 62.5 %, 69. 2% and 54. 5 % by the end of the treatment course, which showed no significant differences between these two groups. Conclusion The standard therapy with the first line anti-tuberculosis drugs should be applied to the initial treating patients with MDR-TB, while the retreating patients should be given individual therapies according to the history of ATT medication and the results of drug susceptibility testing.