320株葡萄球菌的临床分布与耐药性分析

目的了解葡萄球菌的临床分布和耐药特性,为临床合理使用抗感染药物提供依据。方法回顾性调查320株葡萄球菌对13种抗感染药物的耐药性。结果320株葡萄球菌中,金黄色葡萄球菌48株、表皮葡萄球菌121株、溶血葡萄球菌114株,甲氧西林耐药率分别为29.2%、73.6%、和67.5%;万古霉素、呋喃妥因、复方磺胺对葡萄球菌具有较强的抗菌活性。结论凝固酶阴性葡萄球菌是临床主要病原菌,而且对常用抗感染药物比金黄色葡萄球菌更具耐药性,耐甲氧西林葡萄球菌的耐药性比甲氧西林敏感葡萄球菌明显增强。

Analysis of the clinical distribution and drug-resistance of 320 strains of Staphylococcus

Objective To find out the clinical distribution and drug-resistance character of staphylococci for using anti-infective drug reasonably. Method 320 strains of Staphylococcus were reviewed for resisting to 13 anti-infective drugs. Results Among 320 strains of Staphylo- cocci,there ware 48 strains of Staphylococcus auresu,121 strains of Staphylococcus epidermidis and 114 strains of Staphylococcus haemolyticus. Their rates of resisting to methicillin ware 29.2% ,73.6% and 67.5% respectively. The vancomycin, nitrofurantion and trimethoprim/sulfa showed strongantibacterialactivity. Conclusions Staphylococcuswith coagulase-negative is the primary pathogenicbacteriain clinic, and their drug-resistance character is stronger than that of Staphylococcus auresu, The drug-resistance of Staphylococcus resisted to methcillin is stronger than that of Staphylococcus sensitized methicillin.