The skin as a target organ for the investigation of antiallergic drugs: comparison between cetirizine and terfenadine. |
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| Authors: | J P Rihoux L Ghys K Mühlethaler B Wüthrich |
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| Affiliation: | UCB Pharmaceutical Sector, Braine-l'Alleud, Belgium. |
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| Abstract: | Two double-blind clinical pharmacology studies were performed in atopics in order to compare the inhibitory effects of cetirizine (CTZ) 2 HCl and terfenadine (TER) on histamine and antigen-induced skin reactions. In the first study, the subjects took single intakes of CTZ 10 mg and TER 60 mg. In the second study, they took CTZ 10 mg once a day and TER 60 mg b.i.d. for 3 weeks. CTZ was more effective than TER in inhibiting histamine skin reactivity. CTZ and TER were equally effective in inhibiting antigen-induced reactions. There was no tachyphylaxis, either for CTZ or for TER. |
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