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| 基于动态过程的提取工艺优化方法研究 | |
| 引用本文： | 王东喆,章军,张丽艳,王跃生,刘安.基于动态过程的提取工艺优化方法研究[J].中国中药杂志,2012,37(10):1388-1391. |
| 作者姓名： | 王东喆 章军 张丽艳 王跃生 刘安 |
| 作者单位： | 1. 中国中医科学院中药研究所,北京100700;贵阳中医学院,贵州贵阳550002 2. 中国中医科学院中药研究所,北京,100700 3. 贵阳中医学院,贵州贵阳,550002 |
| 基金项目： | 国家重点基础研究发展计划(973)项目(2010CB530600);国家"重大新药创制"科技重大专项(2009ZX09313-038) |
| 摘 要： | 目的:根据提取过程中提取物浓度动态变化过程,建立新的提取工艺优化方法。方法:以三七为示范,比较正交设计优化工艺和动态过程优化工艺所得提取物中指标成分含量、总固体物提取率和指纹图谱相似度,评价动态过程优化方法的可行性。结果:指标成分含量和总固体物得率相差小于5%,指纹图谱相似度100%。说明2种优化工艺所得提取物基本一致,动态过程优化的工艺可以节约79%的提取时间。结论:在提取时间方面,动态过程优化工艺优于正交设计优化工艺,能够大幅度减少提取时间,降低生产成本,值得大规模推广。 |
| 关 键 词： | 动态过程 提取工艺 动态优化 提取时间 |
| 收稿时间： | 2011/12/12 0:00:00 |
Study on optimization method of dynamic extraction process |
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| WANG Dongzhe,ZHANG Jun,ZHANG Liyan,WANG Yuesheng and LIU An.Study on optimization method of dynamic extraction process[J].China Journal of Chinese Materia Medica,2012,37(10):1388-1391. | |
| Authors: | WANG Dongzhe ZHANG Jun ZHANG Liyan WANG Yuesheng and LIU An |
| Institution: | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
| Abstract: | Objective: To establish a new optimized extraction process based on dynamic changes in extract concentration during the extraction process. Method: Sanqi was taken as an example to compare the concentration of marker components, total solids yield and similarity evaluation of the fingerprint images of extracts by orthogonal design optimization process and dynamic optimization process to assess the feasibility of dynamic process optimization method. Result: The concentration of marker components and total solids yield vary less than 5%, with a 100% of similarity in fingerprints, indicating basic coincidence between extracts by the two optimized processes. The dynamic process optimization process could save 79% of the extraction time. Conclusion: In the extraction time, the dynamic optimization process is superior to the orthogonal design optimization process in that it can significantly reduce the extraction time and lower production costs. |
| Keywords: | dynamic process extraction process dynamic optimization process extraction time |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |