儿童幽门螺杆菌感染情况及其与上消化道症状的关系

[目的]探讨儿童幽门螺杆菌（Hp）感染与上消化道症状及胃黏膜病变的关系.[方法]纳入300例有上消化道症状患儿,Hp感染情况采用13C或尿素呼气试验或血清Hp抗体检查,204例患儿接受胃镜检查.[结果]①Hp阳性率为34.67％（103/300）,男女患者Hp阳性率差异无统计学意义（P＞0.05）,3～6岁、7～10岁及11～14岁年龄组Hp阳性率依次升高,组间差异有统计学意义（P＜0.05）;②胃镜检查显示39.21％患儿（80/204）有胃黏膜病变,Hp阳性者胃黏膜病变比例高于Hp阴性者（P＜0.05）;③Hp阴性者胃黏膜病变以轻-中度为主,而Hp阳性者胃黏膜病变以中-重度为主,两者病变严重程度的差异有统计学意义（P＜0.05）.[结论]有上消化道症状儿童Hp阳性率较高,且随年龄增长而增高,Hp感染与胃黏膜病变发生及严重程度相关.

Relationship between Helicobacter pylori infection and upper gastrointestinal symptoms in children

[Objective]To explore the relationship between Helicobacter pylori （Hp）infection and upper gastrointestinal symptoms and gastric mucosal lesion.[Methods]A total of 300 cases of children with upper gastrointestinal symptoms were enrolled.Hp was detected by 13C-urea breath test or serum test of Hp antibody,and 204 cases underwent gastroscopy examination.[Results]①The positive rate of Hp was 34.67％ （103/300）.There was no significant difference in Hp positive rate between male and female patients （P＞ 0.05）.The positive rate of Hp was increased from group （3-6） years,（7-10） years to （11-14） years,and the differences between groups were significant （P＜0.05）.② The gastroscope examination showed that 39.21％ patients （80/204） had gastric mucosal lesion,and the rate of gastric mucosal lesions in Hp positive group was higher than that of Hp negative group （P＜0.05）.③ The gastric mucosal lesions in Hp negative group were mild to moderate,while in Hp positive group they were moderate to severe,and the disease severity was significantly different between two groups（P＜0.05）.[Conclusion]There is a high positive rate of Hp in children with upper gastrointestinal symptoms,and it is increased with the growth of age.Hp infection is associated with severity of gastric mucosal lesions.