首发精神分裂症患者认知功能与精神症状及疗效的关系

目的：探讨首发精神分裂症患者的认知和功能与精神症状及疗效的关系。方法：对１６４例首发精神分裂症患者随机给予氯丙嗪或氯氮平治疗；于治疗前分别作韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击测试、动作功能测验、手功能协调测验、连线测验Ａ和Ｂ、威斯康星卡片分类测验（ＷＣＳＴ）及词语流畅性测验１１项神经心理测查各一次，并作ＢＰＲＳ、ＳＡＮＳ、功能总体评定量表（ＧＡＦ）一次；治疗１２周末再评定１次上

Cognitive Function in First Episode Schizophrenics

Objective: To assess the relationship of cognitive functioning with symptomatology and treatment outcome of first episode schizophrenia Method: First episode schizophrenic patients (n=164) were administered 11 neuropsychological tests prior to randomly assigned treatment with chlorpromazine or clozapine, Weschler Adult Intelligence Scale, Weschler Memory Scale, Grooved Pegboard Test, Finger Taping Test, Edinburgh Handedness Test, Trail Making Test A and B, Wisconsin Card Sort Test, a motor function test,a hand coordination test and a verbal fluency testClinical status was assessed prior to treatment and 12 weeks after starting treatment using the Brief Psychiatric Rating Scale, a Chinese revision of the Scale for Assessment of Negative Symptoms and the Global Assessment of Functioning ScaleResults: Pre-treatment neurocognitive functioning was not related to the severity of positive or negative symptoms before treatment or to the level of improvement in positive or negative symptoms with treatment, but it was significantly related to the severity of positive and negative symptoms after 12 weeks of treatment Conclusion: These results support the hypothesis that neurocognitive functioning, positive symptoms and negative symptoms are independent symptom cluster in schizophrenia