Quipazine has a biphasic effect on slow wave sleep and reduces REM sleep rebound in REM sleep deprived rats |
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Authors: | Richard Zak Miodrag Radulovackp |
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Affiliation: | Richard Zak,Miodrag Radulovackp*, |
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Abstract: | Rats implanted with electrodes for polygraphic recording were deprived of REM sleep for 24 hr. Following REM sleep deprivation animals were injected with quipazine maleate (7.5 mg/kg IP) and were polygraphically recorded for 48 hr. The results show that quipazine reduces REM sleep rebound and that it has a biphasic effect on slow-wave sleep: initial 6 hr suppression is followed by a delayed increase in the second 24 hr recording period. The initial suppression of slow-wave sleep we attribute to the stimulation of central serotonergic receptors while the effect on REM sleep rebound may result from quipazine's action on central catecholamines. |
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Keywords: | Quipazine Slow-wave sleep REM sleep rebound |
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