| 蛋白激酶C抑制剂对SACC-83系P_(21)~(ras)、c-myc表达的影响 |
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| 引用本文： | 孙长伏,李增建,熊鹰. 蛋白激酶C抑制剂对SACC-83系P_(21)~(ras)、c-myc表达的影响[J]. 口腔医学, 1999, 0(1) |
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| 作者姓名： | 孙长伏 李增建 熊鹰 |
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| 作者单位： | 中国医科大学第一临床学院口腔颌面外科，沈阳市第四人民医院口腔科 |
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| 基金项目： | 卫生部及沈阳市科委基金 |
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| 摘 要： | 本实验采用ＰＫＣ抑制剂Ｓｔａｕｒｏｓｐｏｒｉｎｅ作用于ＳＡＣＣ－８３系，观察对Ｐ２１ｒａｓ、ｃ－ｍｙｃ表达的影响．结果表明，Ｓｔａｕｒｏｐｏｒｉｎｅ可明显降低Ｈ－ｒａｓ、ｃ－ｍｙｃ表达程度（ｐ＜０．０１），这提示ＰＫＣ对ｒａｓ、ｃ－ｍｙｃ基因表达具有调控作用，ＰＫＣ抑制剂可能通过调控癌基因的表达来表现抗肿瘤作用的．
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| 关 键 词： | 蛋白激酶C 腺样囊性癌 P_(21)~(ras) c－myc |
Effect of Protein Kinase C Inhibitor on P 21 ras and C-myc of SACC-83 Cell Line |
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| Sun Changfu,Li Zhengjian,Xong Ying.Dept of Oral-Maxillofacial Surgery. Effect of Protein Kinase C Inhibitor on P 21 ras and C-myc of SACC-83 Cell Line[J]. Stomatology, 1999, 0(1) |
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| Authors: | Sun Changfu Li Zhengjian Xong Ying.Dept of Oral-Maxillofacial Surgery |
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| Abstract: | The effect of protein kinase C inhibitor on p 21 ras and c-myc of SACC-83 cell line was studied by using the protein kinase C inhibitor-staurosporine and monoclone antibody of P 21 ras and c-myc.The results showed that expression of H-ras and c-myc was reduced significantly by Staurosporine.It indicated that protein kinase C has a modulating function to ras and c-myc oncogene.Anticancer effect of protein kinase C inhibitor may be accomplished by Modulating oncogene. |
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| Keywords: | Protein kinase C Adenoid cystic carcinoma P 21 ras c-myc |
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