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| 纯音刺激前后正常人听皮层代谢变化~1HMRS研究 | |
| 引用本文： | 梁永辉,陈贤明,李建忠,陈十燕,陈自谦,倪萍. 纯音刺激前后正常人听皮层代谢变化~1HMRS研究[J]. 中华耳科学杂志, 2011, 0(2): 145-148 |
| 作者姓名： | 梁永辉 陈贤明 李建忠 陈十燕 陈自谦 倪萍 |
| 作者单位： | 1. 南京军区福州总医院耳鼻咽喉-头颈外科(福州 350025) 2. 南京军区福州总医院影像科(福州 350025) 3. 南京军区福州总医院医学工程科(福州 350025) |
| 摘 要： | 目的利用质子磁共振波谱(protonmagnetic resonance spectroscopy,1H-MRS)技术研究纯音刺激前后正常人大脑听皮层代谢变化。方法 10例健康受试者双侧听皮层在纯音刺激前后接受两次多体素磁共振波谱检查。刺激声为声强90dB、频率1000Hz的正弦波纯音脉冲,左耳给声。观察双侧听皮层N-乙酰天门冬氨酸(N-aceytlaspartate,NAA)、肌酸(creatine,Cr)、胆碱(choline,Cho)、谷氨酰胺和谷氨酸(glutamate/glutamine,Glx)等代谢物的波峰变化并进行半定量分析。结果左耳纯音刺激后双侧听皮层NAA/(Cho+Cr)、Glx/(Cho+Cr)比值均增高,Cho/Cr比值降低,NAA/(Cho+Cr)、Glx/(Cho+Cr)、Cho/Cr刺激前后差异在右侧听皮层均具有统计学意义(P<0.05),但在左侧听皮层差异无统计学意义(P>0.05)。结论 1HMRS可无创性检测听皮层中与能量代谢及神经递质有关的化合物,纯音刺激单耳时,正常人对侧听皮层代谢变化明显大于同侧,表现为对侧半球传导优势。 |
| 关 键 词： | 磁共振波谱 听皮层 纯音刺激 |
Biochemical changes in auditory cortex in response to pure tone stimulation:a 1H-MRS study |
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| LIA NG Yong-hui,CHEN Xian-ming,LI Jian-zhong,CHENShi-yan,CHEN Zi-qian,NI Ping. Biochemical changes in auditory cortex in response to pure tone stimulation:a 1H-MRS study[J]. Chinese Journal of Otology, 2011, 0(2): 145-148 | |
| Authors: | LIA NG Yong-hui CHEN Xian-ming LI Jian-zhong CHENShi-yan CHEN Zi-qian NI Ping |
| Affiliation: | LIANG Yong-hui1,CHEN Xian-ming1,LI Jian-zhong1,CHEN Shi-yan1,CHEN Zi-qian2,NI Ping3 1 Department of Otolaryngology-Head and Neck Surgery,Fuzhou General Hospital of Nanjing Command,PLA,Fuzhou 350025,China 2 Department of Radiology,China 3 Department of Medical Engineering,China |
| Abstract: | Objective To study biochemical changes in the auditory cortex evoked by pure tone stimuli in healthy subjects using proton magnetic resonance spectroscopy(1H-MRS).Methods MRS tests were performed in 10 healthy volunteers(6 males and 4 females) before and after left ear stimulation with a 1000 Hz pure tone at 90 dB HL.N-aceytlaspartate(NAA),creatine(Cr),choline(Cho) and glutamate/glutamine(Glx) values in the auditory cortex were analyzed with semi-quantitative methodologies.Results The NAA/(Cho+Cr) and Glx/(... |
| Keywords: | Magnetic resonance spectroscopy Auditory cortex Pure tone stimulation |
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