Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum |
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| Authors: | Robert E. Hruska Ellen K. Silbergeld |
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| Affiliation: | Experimental Therapeutic Branch and Section on Neurotoxicology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20205, U.S.A. |
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| Abstract: | Estrogen (125 μg/rat) was administered, subcutaneously, to male rats six days before measurements were made. Estrogen treatment increased the number of dopamine receptor sites labeled by [3H]spiroperidol in vitro and the intensity of stereotypy induced by dopamine agonists in vivo. These two measures suggest that estrogen administration significantly influences the number of striatal DA receptors and a response to in vivo striatal DA receptors stimulation. |
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| Keywords: | Estrogen Dopamine receptors Stereotypy |
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